Search Result for: 用于评估晚期非小细胞肺癌患者循环肿瘤 DNA 突变的定制 15 基因下一代测序面板的分析和临床验证
Analytical and Clinical Validation of a Custom 15-Gene Next-Generation Sequencing Panel for the Evaluation of Circulating Tumour DNA Mutations in Patients with Advanced Non-Small-Cell Lung Cancer
This is a pilot proof-of-concept study to evaluate the utility of a custom 15-gene circulating tumour DNA (ctDNA) panel as a potential companion molecular next-generation sequencing (NGS) assay for identifying somatic single nucleotide variants and indels in non-small-cell lung cancer (NSCLC) patients. The custom panel covers the hotspot mutations in EGFR, KRAS, NRAS, BRAF, PIK3CA, ERBB2, MET, KIT, PDGFRA, ALK, ROS1, RET, NTRK1, NTRK2 and NTRK3 genes which serve as biomarkers for guiding treatment decisions in NSCLC patients.
